Fabrication of Hydroxypropyl Methylcellulose Orodispersible Film Loaded Mirtazapine Using a Syringe Extrusion 3D Printer

Depression is a mental illness causing continuous negative feeling and loss of interest affects physical health. Mirtazapine (MTZ) an effective medicine for treating depression, but patients lack compliance. However, transforming pharmaceutical dosage form to orodispersible film (ODF) could resolve this issue. This study aims fabricate ODF-loading mirtazapine, using syringe extrusion 3D printer, compare its properties with the solvent-casting method. The ODFs were prepared by dissolving mirtazapine in hydroxypropyl methylcellulose E15 solution, then fabricated printer or casting. printing was accurate precise fabricating ODFs. SEM micrographs showed that mirtazapine-printed ODF (3D-MTZ) porous, crystals on film’s surface. 3D-MTZ exhibited better mechanical than mirtazapine-casted (C-MTZ), due 3D-printing process. disintegration time simulated salivary fluid, pH 6.8 at 37 °C, 24.38 s, which faster C-MTZ (46.75 s). vitro dissolution study, 0.1 N HCl found quickly released drug more 80% 5 min. manifested technology can potentially be applied fabrication ODF-containing mirtazapine.